Neil B Ruderman Selected Research

Malonyl Coenzyme A (Malonyl CoA)

3/2006	Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.
2/2006	Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A.
2/2005	AMPK, the metabolic syndrome and cancer.
2/2004	Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.
1/2003	Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation.
5/2002	Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

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Neil B Ruderman Research Topics

Disease

31	Insulin Resistance 12/2016 - 05/2002
13	Type 2 Diabetes Mellitus (MODY) 01/2017 - 10/2002
10	Obesity 12/2016 - 01/2003
9	Hyperglycemia 01/2015 - 03/2002
4	Metabolic Diseases (Metabolic Disease) 01/2017 - 07/2012
4	Atherosclerosis 10/2016 - 05/2004
4	Inflammation (Inflammations) 10/2016 - 09/2010
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2013 - 02/2005
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2014 - 10/2005
2	Overweight 03/2015 - 01/2003
2	Neoplasms (Cancer) 07/2012 - 02/2005
2	Tuberous Sclerosis (Bourneville's Disease) 10/2010 - 02/2005
2	Hyperinsulinism (Hyperinsulinemia) 08/2009 - 05/2002
1	Overnutrition 05/2016
1	Weight Loss (Weight Reduction) 12/2014
1	Morbid Obesity 02/2013
1	Ischemia 08/2011
1	Diabetic Retinopathy (Retinopathy, Diabetic) 06/2011
1	Hyperemia 12/2007
1	Coronary Disease (Coronary Heart Disease) 12/2006
1	Glucose Intolerance 02/2006
1	Hepatocellular Carcinoma (Hepatoma) 11/2004
1	Prostatic Neoplasms (Prostate Cancer) 08/2004
1	Hypertriglyceridemia 02/2004
1	Hypoxia (Hypoxemia) 07/2003
1	Body Weight (Weight, Body) 01/2003
1	Hypoglycemia (Reactive Hypoglycemia) 05/2002

Drug/Important Bio-Agent (IBA)

19	Glucose (Dextrose)FDA LinkGeneric 12/2016 - 05/2002
18	Insulin (Novolin)FDA Link 12/2014 - 05/2002
16	AMP-Activated Protein KinasesIBA 01/2017 - 06/2002
8	Fatty Acids (Saturated Fatty Acids)IBA 02/2015 - 05/2002
6	EnzymesIBA 01/2017 - 12/2002
6	LipidsIBA 12/2016 - 07/2002
6	Malonyl Coenzyme A (Malonyl CoA)IBA 03/2006 - 05/2002
5	ThiazolidinedionesIBA 08/2009 - 01/2005
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 12/2002
4	AdiponectinIBA 07/2006 - 05/2004
3	Sirtuin 1IBA 01/2015 - 07/2012
3	Leucine (L-Leucine)FDA Link 01/2015 - 10/2010
3	Sirolimus (Rapamycin)FDA Link 07/2013 - 02/2005
3	Metformin (Glucophage)FDA LinkGeneric 07/2012 - 11/2004
3	AICA ribonucleotide (ZMP)IBA 10/2011 - 06/2002
3	Nonesterified Fatty Acids (NEFA)IBA 06/2011 - 07/2002
3	DiglyceridesIBA 03/2006 - 06/2002
2	GlycogenIBA 01/2015 - 06/2002
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 07/2013 - 10/2011
2	Pioglitazone (Actos)FDA Link 06/2013 - 02/2004
2	Hypoglycemic Agents (Hypoglycemics)IBA 07/2012 - 08/2009
2	Thioctic Acid (Lipoic Acid)IBA 10/2011 - 10/2010
2	Arginine (L-Arginine)FDA Link 06/2009 - 03/2002
2	Triglycerides (Triacylglycerol)IBA 12/2007 - 03/2006
2	Interleukin-6 (Interleukin 6)IBA 12/2006 - 05/2004
2	Acetyl-CoA CarboxylaseIBA 03/2006 - 11/2004
2	Hormones (Hormone)IBA 02/2006 - 01/2005
2	LeptinIBA 01/2005 - 05/2004
2	Protein Isoforms (Isoforms)IBA 07/2002 - 06/2002
2	Protein Kinase CIBA 07/2002 - 06/2002
1	PalmitatesIBA 10/2016
1	TOR Serine-Threonine KinasesIBA 05/2016
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2014
1	Liraglutide FDA Link 01/2014
1	CalciumIBA 01/2014
1	Messenger RNA (mRNA)IBA 04/2012
1	Branched-Chain Amino AcidsIBA 10/2011
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 08/2011
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 08/2011
1	Fenofibrate (CiL)FDA LinkGeneric 06/2011
1	Retinaldehyde (Retinal)IBA 06/2011
1	MTOR InhibitorsIBA 10/2010
1	Cardiolipins (Cardiolipin)IBA 01/2010
1	Citrate (si)-Synthase (Synthase, Citrate)IBA 01/2010
1	NADH oxidaseIBA 01/2010
1	3-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA 05/2009
1	Transcription Factors (Transcription Factor)IBA 05/2009
1	CholesterolIBA 12/2007
1	AdipokinesIBA 07/2006
1	Acyl Coenzyme A (Acyl CoA)IBA 03/2006
1	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 03/2006
1	PPAR gammaIBA 02/2006
1	Adenosine Monophosphate (AMP)IBA 02/2006
1	Protein Kinases (Protein Kinase)IBA 02/2006
1	Phosphotransferases (Kinase)IBA 02/2005
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2005
1	Leptin ReceptorsIBA 05/2004
1	Coenzyme A (CoA)IBA 01/2003
1	Complement System Proteins (Complement)IBA 12/2002
1	Heparin (Liquaemin)FDA LinkGeneric 07/2002
1	NF-KappaB Inhibitor alphaIBA 07/2002
1	I-kappa B KinaseIBA 07/2002
1	Insulin ReceptorIBA 06/2002
1	malic acid (malate)IBA 05/2002
1	Citric Acid (Citrate)FDA LinkGeneric 05/2002
1	zopolrestatIBA 03/2002
1	Adenosine Triphosphatases (ATPase)IBA 03/2002
1	Aldehyde Reductase (Aldose Reductase)IBA 03/2002
1	Nitroarginine (NG Nitro L Arginine)IBA 03/2002
1	10,10'-dimethyl-9,9'-biacridinium (Lucigenin)IBA 03/2002

Therapy/Procedure

1	Glycemic Control 03/2015
1	Therapeutics 04/2010
1	Bed Rest (Bedrest) 12/2007